1. Study analyzed over 80,000 adults treated for noncancer pain.
2. Severe constipation was linked to opioids like morphine and oxycodone.
3. Tramadol showed a lower risk.
4. Doses over 50 MME/day increased risk significantly.
5. Patients receiving stronger opioids were generally older.
6. Use of enema/suppository defined severe constipation.
7. Findings stress the need for individualized opioid prescribing.

Source: BMC Medicine