- Long-term proton pump inhibitor use was not associated with increased gastric adenocarcinoma risk.
- Adjustment for Helicobacter pylori and lag-time analyses reduced bias.
- Prior positive associations may reflect confounding or reverse causation.
- Absolute gastric cancer risk remained low.
- Clinically indicated proton pump inhibitor therapy should not be withheld based on cancer concern alone.
Source: The BMJ
