A new clinical guideline by the American Gastroenterological Association offers eight recommendations regarding the role of endoscopic surveillance in patients with Barrett's esophagus (BE). A panel provided a conditional recommendation supporting surveillance for patients with nondysplastic BE, as well as for the use of daily proton pump inhibitor therapy compared with no therapy and with anti-reflux surgery to prevent disease progression. For patients with columnar-lined esophagus under 1 cm, endoscopic surveillance was not recommended. However, the panel strongly recommended a combination of high-definition white light endoscopy and chromoendoscopy versus white light endoscopy alone. No recommendation was made on the use of enhanced sampling techniques, such as wide area transepithelial sampling.