AGA recommendations established several key points for clinical practice:
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A four-hour gastric emptying study is recommended.
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Metoclopramide and erythromycin are considered appropriate initial pharmacologic treatments.
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Other pharmacologic agents, including domperidone, prucalopride, aprepitant, nortriptyline, buspirone, and cannabidiol, are not recommended as first-line.
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Procedural interventions, including G-POEM and GES, should be reserved for refractory cases.
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Surgical pyloromyotomy and pyloroplasty remain knowledge gaps.
Source: Gastroenterology
