- High sugar-sweetened beverage (SSB) intake is associated with a significantly increased risk of oral cavity cancer (OCC) in female patients, regardless of smoking or drinking habits.
- Women consuming at least one SSB daily had a 4.87 times (95% CI, 2.47-9.60) higher risk of developing OCC compared to those consuming fewer than one SSB per month.
- Elevated OCC risk was observed across both tongue and nontongue subsites among high SSB consumers.
- Potential mechanisms include chronic inflammation, insulin resistance, oral dysbiosis, and the effects of high fructose corn syrup, a common component of SSBs.
- Although the relative risk increase was substantial, the absolute baseline risk remained low, with an additional 3 OCC cases per 100,000 population among daily SSB consumers.
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