July 21, 2025

Isoflurane Non-Inferior to Midazolam for Pediatric ICU Sedation, Study Finds

A randomized clinical trial in 92 children aged 3 to 17 found inhaled isoflurane as effective as intravenous midazolam in maintaining sedation during mechanical ventilation, with reduced opioid use and quicker extubation times.

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July 21, 2025

Melanoma Risk Differs by Mole Count and Genetic Profile

A large study found distinct genetic and phenotypic risk patterns for nevus-associated and de novo invasive melanomas.

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July 21, 2025

Guselkumab Tops Ustekinumab in Crohns

In a 48-week analysis of 1021 adults with moderate-to-severe Crohn’s disease, guselkumab outperformed placebo and ustekinumab in endoscopic and composite clinical endpoints.

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July 21, 2025

Resistance to Bedaquiline Impacts TB Survival

A cohort study found that patients with bedaquiline-resistant tuberculosis had delayed microbiologic recovery, higher rates of treatment failure, and reduced tuberculosis-free survival at 18 months compared with those with bedaquiline-susceptible disease.

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July 21, 2025

Why Adults Frequently Eat Comfort Food

Researchers explore how psychological expectations—such as boredom relief and mood regulation—drive the frequency of comfort food consumption in adults.

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July 21, 2025

Preeclampsia Risk Scores Under USPSTF Lack Precision, Study Finds

Researchers found that USPSTF guidelines inadequately stratify preeclampsia risk among pregnant patients, particularly those at moderate risk, and therefore limit the utility of aspirin prophylaxis recommendations.

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July 21, 2025

Tracking Meningitis, From Days to Years

Patients from the MeninGene study contributed serum samples over 5 years, revealing that autoimmune processes rarely drive long-term cognitive problems after bacterial meningitis.

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July 18, 2025

Later Eating Linked to Insulin Resistance

A twin study found that individuals who consumed most of their daily calories later in their personal circadian rhythm had lower insulin sensitivity and greater insulin resistance, with genetics playing a role in meal timing behavior.

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July 18, 2025

Blood Test Predicts Organ Aging and Mortality

Researchers used blood proteins to estimate the biological age of 11 organs in over 44,000 people, revealing that older brain and immune systems were linked to higher disease and death risks, while younger ones predicted longer life.

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