- COOKIE-Pro measures covalent drug binding across the proteome.
- Spebrutinib was over tenfold more potent for TEC than BTK.
- Ibrutinib results matched known kinetic benchmarks.
- Over 100,000 kinetic profiles were generated.
- The method may miss low-abundance proteins.
- Hanfeng Lin, PhD, said the probe’s reactivity is vital for effectiveness.
Source: Nature Communications
