A 10-year surveillance study conducted in 10 U.S. states revealed a substantial increase in invasive group A streptococcal (GAS) infections from 2013 to 2022. The incidence rates more than doubled during that time period, with certain populations facing significantly higher risks. The study's authors emphasized a phenomenon of rising antimicrobial resistance and the urgent need for attention and surveillance to guide GAS prevention and control efforts prior to the availability of a licensed vaccine.