- Invasive group A streptococcal (GAS) infections more than doubled from 2013 to 2022 in 10 U.S. states.
- A substantial rise in antimicrobial resistance was also documented.
- Certain populations—such as American Indian or Alaskan Native adults, people living in long-term care facilities or experiencing homelessness, and individuals who inject drugs—faced a significantly higher disease burden.
- The case fatality rate increased with age, reaching almost 22% in those aged 85 years and older.
- Pediatric cases notably decreased by 73% during the COVID-19 pandemic.
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