A recent review published in the World Allergy Organization Journal raises serious concerns about diphenhydramine, a first-generation H₁-antihistamine. The study, led by James H. Clark from Johns Hopkins, highlights its greater impairment of driving performance compared to alcohol and high rates of sedation and psychomotor dysfunction. With over 1.5 million prescriptions written annually, it is widely available over-the-counter in various formulations. The review advocates for the withdrawal of diphenhydramine from the market due to significant public health risks and the availability of safer alternatives.

Source: World Allergy Organization Journal