- Midlife diets and waist-to-hip ratios impact brain connectivity and cognitive function later in life.
- The study had 512 individuals in the diet cohort and 664 in the waist-to-hip ratio cohort.
- Long-term dietary improvements were associated with better brain outcomes.
- Higher AHEI-2010 scores in midlife exhibited associations with improved brain outcomes.
- Waist-to-hip ratio was linked to lower white matter integrity and poorer cognitive performance.
- The study cohort was predominantly male and largely composed of White British individuals with high educational attainment.
- Interventions to improve diet and manage central obesity may be most effective between ages 48 and 70.
Source: JAMA Network Open
