April 17, 2025

Oral Agent Shows Weight, A1c Drops

“As a convenient once-daily pill, orforglipron may provide a new option”—Lilly's oral GLP-1 agent showed up to 7.9% weight loss and HbA1c reductions in phase III diabetes trial.

Reuters

April 17, 2025

Cardiometabolic Shifts May Predict Dementia

An accelerated decline in BMI and waist circumference, along with fluctuating HDL levels, may signal early cognitive impairments up to a decade before dementia diagnosis, study finds.

The Pathologist

April 17, 2025

Early Ezetimibe After MI Tied to Reduced MACE in SWEDEHEART Registry

Delaying ezetimibe use after MI was associated with worse outcomes in a Swedish national cohort study of 35,826 patients.

Conexiant

April 17, 2025

Diet, WHR Linked to Late-Life Brain Connectivity

"These findings suggest that interventions to improve diet and manage central obesity might be best targeted in middle to older age," concludes the Whitehall II cohort study showing how midlife metrics correlate with hippocampal connectivity and cognitive function at age 70.

Conexiant

April 17, 2025

Eyebrows Signal Understanding Gaps in Conversation

Eyebrow furrows can silently signal 'I've not received enough information,' researchers found, as these facial cues influenced the likelihood and type of verbal repair in conversation.

Conexiant

April 16, 2025

Newer Glucose-Lowering Drugs Reduce CV Events in Older Adults

"Use of GLP1-RAs and SGLT-2is was associated with reduced rates of 3P-MACE and HHF compared to DPP-4is, independent of age" - findings from a Danish nationwide study of 35,679 patients aged 70 and older with T2D.

Conexiant

April 16, 2025

Triple Drug Combo May Halt Enterovirus Infections

All three components have previously completed clinical trials for other applications and established safety profiles in humans.

Conexiant

April 16, 2025

E-Cigs + Cigarettes: Worse Disease Odds

"There is a need to reassess the assumption that e-cigarette use provides substantial harm reduction across all cigarette-caused diseases, particularly accounting for dual use," warns a comprehensive meta-analysis.

Conexiant

April 16, 2025

CONSORT 2025: Setting New Standards for Clinical Trial Reporting

"Readers should not have to infer what was probably done; they should be told explicitly." This principle drives the comprehensive CONSORT 2025 update, with its 7 new checklist items aimed at improving clinical trial transparency.

Conexiant