5 Key Takeaways

• 1

  A 52-week trial found intermittent energy restriction (IER) produced similar weight loss to continuous energy restriction (CER) in adolescents with obesity.

• 2

  Both IER and CER groups achieved significant reductions in BMI z-score at 52 weeks, with no significant differences in body composition or cardiometabolic outcomes.

• 3

  Insulin resistance improved in both groups at 16 weeks but was maintained only in the CER group at 52 weeks.

• 4

  Withdrawal rates were higher in the IER group (39.4%) compared to the CER group (22.9%).

• 5

  Adverse events were reported in 47.5% of participants, with eight serious adverse events occurring across six participants.