5 Key Takeaways

• 1

  Higher body mass index (BMI) is linked to a 30% increased risk of hospitalization for bacterial infections and a 32% increased risk for severe viral infections.

• 2

  Mendelian randomization analysis indicates that higher BMI is a causal factor for severe bacterial and viral infections.

• 3

  Each 10 mmol/mol increase in HbA1c is associated with a 32% higher risk of bacterial infection hospitalization and a 29% higher risk of severe viral infections.

• 4

  Weight-loss interventions may reduce the risk of severe infections in individuals with high BMI, particularly those with diabetes.

• 5

  The study highlights the need for tailored weight management strategies for individuals with diabetes at high risk of infection.