Eighty-four percent of adults with congenital heart disease may report good or better quality of life, according to a recent study cohort study from the Congenital Heart Initiative registry. 

In the study, published in JAMA Network Open, investigators analyzed patient-reported outcomes among 4,558 adults with congenital heart disease (CHD), representing the largest registry of adults with CHD in the United States. 

Overall, 84% of the participants rated their health-related quality of life as good or better, with no statistically significant differences observed by CHD complexity. However, the participants with complex CHD were less likely to meet recommended physical activity guidelines compared with those with moderate CHD (χ²₂ = 15.9, n = 3,320, P < .001), with this disparity being more pronounced among female participants. 

Despite the high reported quality of life, 88% of the participants reported at least one comorbidity. The most common cardiac comorbidity was arrhythmia (33%), and the most frequently reported noncardiac condition was mood disorders such as anxiety or depression (35%).

The findings highlighted areas that may warrant further investigation, particularly in addressing physical activity and mental health in adults with congenital heart disease.

Full disclosures can be found in the published study.