Clinical Report: Hair Repigmentation Reported With Baricitinib in Canities Subita

Overview

This case report describes hair repigmentation and regrowth in a 60-year-old male patient with canities subita and alopecia areata following treatment with baricitinib.

Background

Canities subita, characterized by sudden hair whitening, lacks established treatment options.

Data Highlights

No numerical data or trial data were provided in the article.

Key Findings

• A 60-year-old male with rheumatoid arthritis experienced sudden hair whitening and alopecia areata.
• Baricitinib 4 mg/day was initiated after discontinuation of etanercept.
• Signs of pigmented hair appeared 4 months post-initiation, with complete hair repopulation by 8 months.
• The patient’s rheumatoid arthritis remained in clinical remission throughout the treatment.
• No adverse events were reported during the treatment period.

Clinical Implications

Clinicians should consider the safety risks associated with Janus kinase inhibitors when evaluating treatment options.

Conclusion

This case report provides evidence for the use of baricitinib in canities subita.

Related Resources & Content

1. Corbella-Bagot L, et al., International Journal of Trichology, 2023 -- Hair Repigmentation Reported With Baricitinib in Canities Subita
2. Baricitinib Demonstrates Efficacy in Refractory Rheumatoid Arthritis
3. conexiant — Baricitinib Mono vs Combo: 6-Year RA Data
4. Dermatology and Therapy (Springer) — Real-World Use of Baricitinib in Patients with Atopic Dermatitis in Spain: DAMA-S Study, A Retrospective Chart Review
5. conexiant — Rare Skin Reaction Reported With Tirzepatide
6. Baricitinib Demonstrates Efficacy in Refractory Rheumatoid Arthritis
7. Overview | Baricitinib for treating severe alopecia areata | Guidance | NICE
8. British Association of Dermatologists living guideline for managing people with alopecia areata 2025
9. Japanese Dermatological Association's Clinical Practice Guidelines for Alopecia Areata 2024: A Complete English Translated Version - Ohyama - 2025 - The Journal of Dermatology - Wiley Online Library
10. Baricitinib Withdrawal and Retreatment in Patients With Severe Alopecia Areata: The BRAVE-AA1 Randomized Clinical Trial - PMC
11. Outcomes of down-titration in patients with severe scalp alopecia areata initially treated with baricitinib 4-mg: Week 152 data from BRAVE-AA2 - PubMed
12. Frontiers | Safety of oral JAK inhibitors in treating alopecia areata: a systematic review and network meta-analysis
13. Successful Treatment of Canities Subita with Baricitinib - PMC
14. Unexpected Extensive Hair Whitening Following Baricitinib Treatment for Alopecia Universalis: A Case Report and Mechanistic Insights - PMC
15. International Journal of Trichology