This randomized controlled trial aims to evaluate the effectiveness of a fixed nitrous oxide and oxygen mixture in reducing pain and anxiety during ultrasonic supragingival scaling compared to oxygen alone. Enrolling 120 adults with stage I to IV periodontitis and dentin hypersensitivity, the study will assess primary outcomes like pain and anxiety with validated scales at multiple time points. Secondary outcomes will include vital signs and adverse effects. The findings may enhance clinical practices in dental sedation and ensure patient comfort during procedures.

Source: BMJ Open