- A randomized trial of nearly 1,200 patients tested gabapentin after major cardiac, thoracic, and abdominal surgery.
- Gabapentin did not reduce hospital stay or improve recovery when added to multimodal analgesia.
- Early pain and opioid use were slightly lower with gabapentin but differences disappeared after two days.
- At 4 weeks and 4 months, more patients on gabapentin reported pain, and quality-of-life scores were unchanged.
- Adverse events were similar between groups. Researchers concluded gabapentin offered no recovery advantage after major surgery.
Source: Anesthesiology