New preclinical data presented at the 2025 EULAR Congress suggest that aconitine, a compound in Aconiti Lateralis Radix Praeparata, has bone-protective and immune-regulating effects in rheumatoid arthritis using a collagen-induced arthritis mouse model. The study, conducted by investigators from Peking University People’s Hospital and Dongfang Hospital Beijing University of Chinese Medicine, evaluated aconitine’s effects on arthritis severity, synovial inflammation, and bone erosion, supporting its potential as a modulator of immune response and protector of bone integrity in inflammatory arthritis.

Source: EULAR 2025, Abstract ABS0005: "Aconitine: A Potential Treatment for Rheumatoid Arthritis"