1. Antidepressants show wide variation in short-term cardiometabolic effects.
2. Weight changes range from modest loss with agomelatine to notable gain with tricyclics.
3. Several agents alter heart rate and blood pressure in clinically relevant ways.
4. Some antidepressants raise cholesterol or hepatic enzymes despite stable weight.
5. Drug choice should account for a patient’s cardiovascular, metabolic, and hepatic risk profile.

Source: The Lancet