- Genetic risk overlapped widely across 14 psychiatric disorders.
- A five-factor structure explained about 66 percent of within-disorder genetic variance.
- Same-factor disorders had high genetic correlations (some exceeded 0.8).
- Analyses identified 238 factor-linked loci and 412 disorder-differentiating loci.
- Signals mapped to regulatory biology and early brain development; ancestry diversity was limited.
Source: Nature
