1. Both written exposure therapy (WET) and selective serotonin reuptake inhibitors (SSRIs) produced clinically meaningful posttraumatic stress disorder (PTSD) symptom improvement in primary care patients.
2. Treatment engagement was higher with SSRIs (52%) than with WET (32%).
3. Nonresponders to SSRIs benefited more from switching to venlafaxine than from adding WET.
4. Venlafaxine yielded greater reductions in PTSD, depression, anxiety, and sleep disturbance scores.
5. Findings support SSRIs and WET as first-line options, with venlafaxine as an effective second-line strategy.

Source: JAMA Psychiatry