- Opioid use disorder (OUD) led to weakened brain responses to positive emotional experiences.
- Mindfulness-Oriented Recovery Enhancement (MORE) demonstrated improved brain responses to positive stimuli and reduced craving in individuals with OUD.
- Weaker late positive potential (LPP) responses correlated with elevated opioid craving.
- The therapy also resulted in reduced symptoms of anhedonia.
- Oxycodone, hydrocodone, and tramadol were commonly used opioids among the participants.
- The study emphasized that mindfulness-based therapies may normalize reward system function in individuals with OUD.
Source: JAMA Psychiatry
