1. Gabapentin use was associated with approximately 80% higher odds of depression after adjustment for demographic, lifestyle, and clinical variables.
2. The link between gabapentin and depression was most pronounced among women and patients reporting less than 7 hours of sleep per night.
3. U.S. Food and Drug Administration’s Adverse Event Reporting System data showed 9,951 gabapentin-related adverse events, including 1,165 (11.7%) psychiatric cases; suicidal ideation was the most frequently reported (22.6%).
4. Among psychiatric reports, insomnia demonstrated the strongest association in disproportionality analysis.
5. While causality cannot be confirmed, physicians should monitor mood and sleep patterns in patients prescribed gabapentin, particularly those with preexisting mental health or sleep concerns.

Source: Medicine