Depression, whether experienced in midlife or late life, is associated with an increased risk of developing dementia, according to a comprehensive analysis of over three million people. The risk persists regardless of when depression is diagnosed and appears to be a potential independent risk factor for dementia. The findings support the importance of early screening, sustained treatment, and public health strategies to address midlife depression as a crucial factor in preventing dementia. Further research is needed to understand the biological pathways and determine the potential of treating depression in preventing or delaying dementia onset.

Source: eClinicalMedicine