Increased alcohol use in individuals with bipolar disorder is significantly associated with heightened depressive and manic symptoms over the subsequent six months, particularly pronounced in those with bipolar disorder type II.
A recent cohort study published in JAMA Network Open examined the relationship between alcohol use and mood, anxiety, and functioning in individuals with bipolar disorder (BD). The investigation utilized data from 584 adults enrolled in the Prechter Longitudinal Study of Bipolar Disorder (PLS-BD).
Key Findings:
Higher levels of alcohol use were linked to decreased workplace functioning in subsequent months, especially in individuals with bipolar disorder type II (BDII). Conversely, increased mood symptoms did not predict subsequent alcohol use.
No significant association was found between alcohol use and anxiety levels over time.
Participants were drawn from the PLS-BD, an ongoing cohort study recruiting from psychiatric clinics, mental health centers, and community outreach events across Michigan. The study included individuals diagnosed with BDI or BDII who had been enrolled for at least five years, with follow-up durations ranging from five to sixteen years. The Alcohol Use Disorders (AUD) Identification Test was employed to measure alcohol use, while standardized scales assessed depression, mania or hypomania, anxiety, and functioning.
The study underscores the need for regular monitoring of alcohol consumption, even at subclinical levels, due to its potential impact on mood stability and workplace functioning. Given the high prevalence of alcohol use disorder (AUD) among BD patients and its negative effects, concurrent treatment of both conditions may enhance clinical outcomes.
These findings indicate that alcohol use is associated with mood instability and impaired workplace functioning in individuals with BD. They suggest that comprehensive and integrated treatment approaches addressing both BD and AUD could be beneficial.
Funding for the study was provided by the National Institute of Mental Health.
