5 Key Takeaways

• 1

  Lithium therapy significantly reduced symptom severity in adolescents with emotional dysregulation at 6 months compared to standard treatment.

• 2

  At 12 months, both lithium and control groups showed reduced symptom severity, but no significant differences were observed between them.

• 3

  The lithium group had more complex clinical profiles at baseline, including higher rates of prior treatment and psychiatric hospitalizations.

• 4

  Adverse effects were more common in the lithium group, with metabolic, neurological, and endocrine issues being the most frequent.

• 5

  The study's limitations include a small sample size and lack of randomization, impacting the generalizability of the findings.