- Infants on early acid-suppressive therapy had a 52% higher risk of celiac disease autoimmunity (CDA).
- A test-negative case-control study suggested the association might not be causal, identifying potential confounding factors.
- Longer AST use was linked to a higher risk of CDA.
- The study relied on serologic tests for CDA diagnosis, with biopsy confirmation not required.
- The limitations included incomplete information on reasons for CDA testing and rising rates of AST use and CDA in Israel.
Source: JAMA Network Open
