Clinical Report: Can Mecobalamin Prevent Pain Syndrome After Foot and Ankle Surgery?
Overview
Prophylactic mecobalamin was associated with a lower incidence of complex regional pain syndrome type 1 (CRPS-1) following foot and ankle surgery. The study reported a lower occurrence of CRPS-1 in patients receiving mecobalamin compared to those receiving placebo.
Background
Complex regional pain syndrome (CRPS) can develop after surgical procedures, leading to chronic pain and disability. Preventive strategies are crucial for improving postoperative outcomes, particularly in high-risk populations. This study evaluates the efficacy of mecobalamin, a form of vitamin B12, in preventing CRPS-1 after foot and ankle surgery.
Data Highlights
| Group | CRPS-1 Incidence | Adjusted Absolute Risk Reduction | Number Needed to Treat |
|---|---|---|---|
| Mecobalamin | 2% | 8% | 14 |
| Placebo | 9% | - | - |
Key Findings
- 2% of patients receiving mecobalamin developed CRPS-1 compared to 9% in the placebo group.
- The adjusted absolute risk reduction for CRPS-1 was approximately 8% with mecobalamin.
- The number needed to treat to prevent one case of CRPS-1 was 14.
- Patients in the mecobalamin group reported greater improvement in postoperative pain compared to the placebo group.
- Functional improvements in activities of daily living were noted with mecobalamin, as measured by the Foot and Ankle Ability Measure (FAAM).
- Statistically significant treatment effects were observed, although the magnitude was described as modest.
Clinical Implications
The findings indicate that mecobalamin may reduce the incidence of CRPS-1 after foot and ankle surgery.
Conclusion
Prophylactic mecobalamin was associated with a lower incidence of CRPS-1 in patients undergoing foot and ankle surgery. Further studies are needed to confirm these findings in larger, multicenter trials.
Related Resources & Content
- Arunakul M, et al., JBJS Open Access, 2025 -- Can Mecobalamin Prevent Pain Syndrome After Foot and Ankle Surgery?
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