Objective:

To evaluate the impact of bone morphogenetic protein-2 (BMP-2) augmentation on radiographic bone consolidation and implant survivorship in revision total hip arthroplasty (THA) for severe acetabular defects, highlighting its potential significance in improving surgical outcomes.

Key Findings:

• 83% of hips showed more than 50% radiographic bone consolidation at final follow-up.
• No cases of graft resorption were observed.
• Implant survivorship was 90% at 6 years and 70% at 10 years when defined by all-cause reoperation.
• Survivorship was 90% at both time points when defined by acetabular loosening.
• Mean Oxford Hip Score among 13 hips was 35 at a mean of 84 months.
• 28% of hips experienced postoperative complications.

Interpretation:

BMP-2 augmentation appears to enhance bone consolidation and midterm implant survivorship in revision THA for severe acetabular defects, although further studies are necessary to confirm these findings.

Limitations:

• Retrospective study design, which may introduce bias.
• Small sample size limits generalizability.
• Lack of a control group makes it difficult to draw definitive conclusions.
• Absence of preoperative patient-reported outcomes limits understanding of baseline function.
• No cost-effectiveness analysis was performed.
• Single-surgeon experience at a tertiary referral center may not reflect broader practice.

Conclusion:

BMP-2 augmentation is associated with positive outcomes in revision THA for severe acetabular defects, warranting further investigation into its safety and efficacy to validate these promising results.