Objective:

To evaluate the efficacy of ST-Lysyal (T-Lys) compared with hyaluronic acid eye drops in patients with dry eye disease (DED).

Approach:

• Study Design: A double-masked, randomized trial conducted at the Ocular Surface and Dry Eye Center, University of Milan with 27 patients diagnosed with DED.
• Intervention: The treatment group received T-Lys eye drops 3 times daily for 2 months, while the control group received 0.2% hyaluronic acid combined with tamarind seed polysaccharide.
• Outcomes Measured: Symptom severity (SANDE scores), tear film breakup time (T-BUT), and corneal and conjunctival staining.

Key Findings:

• T-Lys group showed significant improvement in symptom severity from 4.58 ± 2.57 mm at baseline to 2.92 ± 1.38 mm at two months.
• T-BUT increased from 2.58 ± 1.31 seconds to 3.58 ± 1.37 seconds in the T-Lys group.
• Corneal staining decreased from 2.16 ± 4.17 to 1.41 ± 3.70 in the T-Lys group.
• Control group showed no significant improvement in symptom severity from 5.13 ± 2.29 mm to 5.3 ± 2.4 mm, T-BUT from 3.07 ± 1.43 seconds to 3 ± 1.13 seconds, or corneal staining.
• No adverse events were reported in either group.

Interpretation:

Limitations:

• Small sample size of 27 patients.
• Short duration of the study (2 months).
• No significant improvements in conjunctival staining were observed.

Conclusion:

Sources:

• Ophthalmology and Therapy Article