5 Key Takeaways

• 1

  Nearly 3% of women aged 40 to 74 without breast cancer carried pathogenic variants in breast cancer susceptibility genes.

• 2

  30% of these variant carriers would not qualify for testing under current family history-based guidelines.

• 3

  The study enrolled 30,192 women in the personalized screening arm of the WISDOM trial, integrating genetic testing into risk assessment.

• 4

  Demographic analysis showed higher proportions of pathogenic variants in younger women and specific ancestry patterns.

• 5

  The study highlights an implementation gap in testing guidelines, as many carriers lacked family history risk factors.