In this retrospective cohort study of US adults aged 65 years and older, receipt of a high-dose inactivated influenza vaccine was associated with a significantly lower risk of incident Alzheimer dementia compared with a standard-dose vaccine over up to 25 months of follow-up, with a more sustained effect observed among women. These findings suggest that enhanced influenza vaccination strategies may confer neuroprotective benefits beyond infection prevention, although results were limited by potential residual confounding, short follow-up duration, and reliance on claims-based dementia definitions.

Source: Neurology