- Inebilizumab showed promise in improving function and reducing disease severity in patients with generalized myasthenia gravis.
- Participants receiving inebilizumab demonstrated greater improvement in MG-ADL scores at 26 weeks compared with placebo.
- The trial emphasized the potential efficacy of targeting CD19+ B cells in depleting antibody-secreting cells.
- Inebilizumab was found to have a significant safety profile, with some adverse events reported.
- Further data are essential to confirm the long-term safety and efficacy of inebilizumab, as highlighted by the researchers.
- MINT was a phase III trial involving 238 participants with generalized myasthenia gravis from 18 countries, focusing on the efficacy of inebilizumab in improving patient outcomes.
Source: New England Journal of Medicine