1. Vitamin B12 may protect against acute pancreatitis by preventing cell death and supporting energy production.
2. Higher genetically predicted levels of vitamin B12 are associated with a lower risk of developing acute pancreatitis.
3. Mice lacking the receptor for vitamin B12 uptake developed more severe pancreatitis, but treatment with vitamin B12 reduced pancreatic damage and improved energy levels.
4. Vitamin B12's protective effect stems from restored energy metabolism, particularly its function in the succinyl-CoA pathway to boost ATP production.
5. Clinical trials are necessary to determine whether early administration of vitamin B12 in patients can reduce disease severity.

Source: MedComm