- Ultra-hypofractionated radiotherapy over 2.5 weeks is as effective as standard 8-week course for localized prostate cancer.
- Long-term outcomes confirm durable cancer control and similar adverse effects.
- The trial, HYPO-RT-PC, enrolled 1,200 men with intermediate- to high-risk localized prostate cancer.
- Failure-free survival after 10 years: 72% (short-course) vs 65% (standard-course).
- Overall survival after 10 years: 81% (short-course) vs 79% (standard-course).
- Urinary and bowel symptoms were similar in both groups, with most being mild to moderate.
Source: ESTRO 2025