- Kidney dysfunction and anemia elevate plasma phosphorylated tau 217 (p-tau217) levels, independent of amyloid burden.
- Biologically adjusted p-tau217 cutoffs improve diagnostic accuracy, especially in advanced chronic kidney disease.
- Double-cutoff strategies perform best in obesity but increase indeterminate results requiring positron emission tomography.
- Normalized p-tau217 ratios are less affected by systemic factors than absolute levels.
- Uniform p-tau217 cutoffs risk misclassification in patients with common comorbidities.
Source: JAMA Neurology
