A two-cohort prospective study identified 27 oral microorganisms significantly linked to pancreatic cancer risk, showing that higher microbial risk scores correspond with increased likelihood of disease. Conducted with 122,000 participants over nine years, the study found specific bacteria and fungi such as Porphyromonas gingivalis and Candida to be associated with elevated risk. This research reveals the potential of oral microbiota as biomarkers for earlier pancreatic cancer detection and suggests possible translocation pathways from the oral cavity to pancreatic tumors.

Source: JAMA Oncology