A study led by researchers at City of Hope has revealed how mapping the genetic material surrounding chromosomes in brain tumors can aid in developing personalized therapies for patients with glioma. By utilizing spatial transcriptomics and DNA sequencing, the research identified the presence of extrachromosomal DNA (ecDNA) in brain tumor samples, driving rapid oncogene amplification and adaptation to tumor microenvironments. This foundational knowledge may lead to more precise and effective treatments tailored to the unique biology of each patient.

Source: Nature Communications