- Mapping genetic material in brain tumors may aid in personalized therapies for glioma patients.
- Extrachromosomal DNA (ecDNA) drives rapid oncogene amplification and tumor adaptation.
- Presence of ecDNA linked with hypoxic tumor environments and poor clinical outcomes.
- Integration of spatial transcriptomics and DNA sequencing may reveal evolutionary history of tumor cells.
- Study supports the development of personalized cancer therapies by uncovering unique biological features.
Source: Nature Communications
