In a randomized clinical trial of 1,658 patients aged 12 years and older with urinary stone disease and low baseline urine volume, a multicomponent behavioral intervention significantly increased urine output compared with guideline-based care but did not reduce symptomatic stone recurrence over a 2-year follow-up period (19% vs 20%; hazard ratio, 0.96). Despite higher urine volumes and modest early differences favoring the intervention, there were no between-group differences in new stone formation, stone growth, or composite outcomes, and increased urinary symptoms were observed at select timepoints.

Source: The Lancet