Recent study findings reveal that cannabidiol (CBD) and cannabidivarin (CBDV) exhibit antifungal activity against Cryptococcus neoformans and other clinically significant fungal pathogens. The compounds demonstrate multiple mechanisms of action, including biofilm inhibition, membrane destabilization, and disruption of metabolic and stress response pathways. In addition to in vitro testing, the study also highlights the in vivo efficacy of CBD in a Galleria mellonella burn wound model infected with C neoformans. These promising results offer potential for the development of topical or oral antifungals for patients.

Source: PLOS Neglected Tropical Diseases