- Cannabidiol (CBD) and cannabidivarin (CBDV) exhibited antifungal activity against Cryptococcus neoformans and other clinically significant fungal pathogens.
- The compounds demonstrated multiple mechanisms of action, including biofilm inhibition, membrane destabilization, and disruption of metabolic and stress response pathways.
- CBD showed promising results in a Galleria mellonella burn wound model infected with C neoformans, indicating potential for future development of topical or oral antifungals.
- The study findings offer important insights for the prevention or eradication of cryptococcal colonization of medical prosthetic devices.
- CBD and CBDV may represent novel strategies for antifungal treatments with broad activity against fungal pathogens, including dermatophytes and Candida species.
Source: PLOS Neglected Tropical Diseases
