- Adjuvanted and high-dose flu vaccines showed equivalent protection against lab-confirmed influenza in adults 65+.
- The study included 429,595 older adults across 65 Kaiser Permanente Northern California facilities using a cluster randomized crossover design.
- Relative vaccine effectiveness of adjuvanted vs high-dose vaccine was 1.5% (95% CI, −8.4% to 10.5%), indicating no statistically significant difference.
- Secondary outcomes—including influenza-related hospitalization/ED visits and community-acquired pneumonia—were also similar between vaccine groups.
- Findings reinforce ACIP recommendations that both adjuvanted and high-dose influenza vaccines are appropriate preferential choices for older adults.
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