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Conexiant chevron_right Infectious Disease chevron_right AmoxicillinClavulanate vs Amoxicillin for Sinusitis
From the Journals Conference News ESCMID GLOBAL 2026 CONGRESS

Amoxicillin-Clavulanate vs Amoxicillin for Sinusitis

Amoxicillin-clavulanate was not linked to lower treatment failure but was associated with a slightly higher risk of secondary infections compared with amoxicillin in adults with uncomplicated acute sinusitis.

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  1. No difference in treatment failure
  2. Low overall failure rate (~3%)
  3. Similar adverse event rates
  4. Higher secondary infection risk with amoxicillin-clavulanate
  5. Amoxicillin favored as first-line

Source: JAMA

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