- Increase in spironolactone prescriptions for androgen-related dermatologic conditions among young women and girls aged 12 to 40 years from 2000 to 2020.
- Acne, hirsutism, and polycystic ovary syndrome were the most common diagnoses.
- Off-label use of spironolactone has become widespread for these dermatologic conditions, usually requiring higher doses than those used for cardiovascular indications.
- Further safety research is needed to evaluate high-dose spironolactone use in younger populations.
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