1. 7-day cold water acclimation can improve cellular cold tolerance.
2. Daily exposure to cold water transitioned cellular response to improved cytoprotective mechanisms.
3. Cold exposure may enhance autophagic function and contribute to human health.
4. LC3-II and p62 protein expression indicated improved cellular responses after acclimation.
5. Cold water immersions produced an insulative pattern of cold acclimation.
6. Time to reach a cutoff temperature extended from 40 minutes to 55 minutes on day 7.
7. Cold exposure could be a non-pharmacological intervention to improve autophagic function.

Source: Advanced Biology