1. Over 6% of tested serum samples across Latin America showed Oropouche virus antibodies.
2. IgG seropositivity was associated with increasing age, consistent with long-term antibody persistence.
3. The study identified high-risk areas in the Amazon River basin, southern Brazil, Central America, and the Caribbean.
4. Genomic analyses revealed minimal divergence between OROV strains, suggesting climatic and ecological conditions are key drivers of transmission.
5. Enhanced diagnostics, targeted surveillance, and vector control are needed to mitigate future OROV outbreaks.

Source: The Lancet Infectious Diseases