Among elderly hypertensive patients with a BMI >30, vitamin D supplementation consistently reduced blood pressure at both high (3750 IU/day) and low (600 IU/day) doses, with systolic pressure decreasing from 139.3±15.3 to 126.7±10.7 mm Hg (P<.001) over 12 months.
Low-magnitude mechanical signals may boost tibial cross-sectional area in adolescents with anorexia, potentially offering a non-exercise alternative for bone health.
New scientific statement reveals that up to 85% of males on methadone maintenance therapy develop hypogonadism, while opioids can trigger a cascade of endocrine disruptions affecting multiple hormone systems from bone metabolism to prolactin levels, findings especially critical as opioid prescriptions reached 131.7 million in the U.S. in 2022.
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A study reveals that while Notch signaling drives early RA pathology through neovascularization, anti-TNF therapy specifically reduced JAG1/2 and DLL1/4 transcription in synovial tissue myeloid cells, but only in good responders (ΔDAS28 >1.2 with DAS28 ≤3.2 at 12 weeks).
The USPSTF's draft recommendations reaffirm osteoporosis screening for older women, call for more research on screening men, and address health disparities.
A 20-year study reveals that patients with osteoarthritis have a higher risk of severe multimorbidity, emphasizing the need for comprehensive health care strategies beyond joint health.