- Nageotte nodules are associated with widespread sensory neuron loss in diabetic peripheral neuropathy.
- The nodules primarily consist of satellite glial cells and nonmyelinating Schwann cells expressing specific markers.
- RNA sequencing revealed potential signaling between nodules and adjacent neurons.
- The findings provide insights into the mechanisms of sensory neuron degeneration and the possible role of support cells in disease progression.
- Identifying the molecular pathways involved could inform future research on neuroprotection and pain regulation in diabetes.
Source: Nature Communications
